Multi Component Reactions are valuable transformation to access complex structures starting from
three or more, relatively, simple compounds through a sequential multi-bond formation process;1
thanks to their convergent, green and atom economical features, they’re applied in several fields
such as natural products and drug synthesis.2 Asymmetric MCRs are even more advantageous in
consequence of the installation of single or multiple chiral centers.3 In my literature seminar, I will
discuss the main groups of MCR and their stereoselective procedures.
1- I. Ugi, A. Dömling, W. Hörl, Endeavour., 1994, 18, 115–122; J. Zhu, H. Bienayme
(Eds.) Multicomponent reactions. Wiley-VCH Verlag gmbH, Weinheim, Germany, 2005.
2- E. Ruijter, R. V. Orru, Drug Discovery Today: Technol., 2013, 10, e15–e20; B. B. Touré and
D. G. Hall, Chem. Rev., 2009, 109, 4439-4486.
3- D. J. Ramon, M. Yus Angew. Chem. Int. Ed., 2005, 44, 11, 1602 – 1634; P. S. Gonçalves
Nunes, H. D. Almeida Vidal, A. G. Corrêa Org. Biomol. Chem., 2020, 18, 7751–7773