The Chemistry of Alzheimer’s Disease Alzheimer’s disease is a severe brain disorder that damages neurons, especially in areas linked to memory, language, and cognition. In this seminar, I will discuss the chemistry behind the disease, specifically focusing on Amyloid Beta (Ab) snail plaques and the role of different metals in forming these plaques.
The seminar will start by highlighting how specific metals in Amyloid structures affect the stability, insolubility, and toxicity of metal-Ab structures. Exploring the interactions between these metals and Ab plaques is crucial for understanding how they cause aggregation and damage to neuronal cells. The discussion will also cover the catalytic role of these structures in forming Reactive Oxygen Species (ROS), which worsen neuronal damage.
The seminar will then proceed to the detailed process of ROS formation. Towards the end, I will focus on metal chelation therapeutic approach. The chelating method involves removing the metals involved in Ab plaque formation, disrupting the stable structure, and promoting a soluble Ab form. I will present a natural product that presents chelating abilities and potentially serves as a metal’s chelator.