Ilan Marek

Ilan Marek

Organic synthesis, stereoselective synthesis.

We are concerned with the design and development of new and efficient stereo- and enantioselective strategies for the synthesis of important complex molecular structures. We are particularly interested in developing carbon-carbon bond forming processes, which efficiently create multiple stereocenters in a single-pot operation. Deep understanding of reaction mechanisms gives insight into the origins of chemo- and stereoselectivity, and governs optimization towards the most efficient and general protocols for our methodologies. Our vision is that we should provide an answer to challenging synthetic problems but it has to be coupled with unique efficiency and elegance.

Prof. Marek has received several awards for his research, including the First French Chemical Society-Acros Price for young Organic Chemist (under 40 years old in 1997); the Japan Society for the Promotion of Science Visiting Professor Award (1997); the Lawrence G. Horowitz Career Development Chair (1998); the Yigal Alon Fellowship (1998); Evelyn and Salman Grand Academic Lectureship-USA (1998); the Yosefa and Leonid Allschwang award, administrated by the Israel Science Foundation (2000); the Michael Bruno Memorial Award 2002, administrated by the Rothschild Foundation (2002); the Prize for Excellent Young Chemist, The Israel Chemical Society (2004); the Merck Sharpe and Dohm Lecturer (2005); the Bessel Award of the Humboldt Foundation, Germany (2007), the Taub Award for academic excellence (2009), The German-Technion Award for Academic Excellence and Scientific Collaborations, (2010), the Royal Society Chemistry organometallic Award from the RSC (2011), the Taiwan National Science Council Visiting Scholar (2011), the Janssen Pharmaceutica Prize for Creativity in Organic Synthesis (2012), the Israel Chemical Society Award for Excellence (2012), the Moore Distinguished Scholar Appointment at the California Institute of Technology (2013), the Eli Lilly lecturer at Urbana Champaign, Il, USA (2014), the SFB-guest Professor Wilhelms-University Munster, Germany (2015), the Joseph and Patricia Vanderslice Lecturer, Boston College (2015), the 17th International Organic Chemistry Foundation Yoshida Lectureship, Japan (2015), the Weizmann Prize for Exact Sciences (2015) and the YannaiAward for excellence in teaching (2016).

1) Alkene Isomerization through Allylmetals as a Strategic Tool in Stereoselective Synthesis

Itai Massad and Ilan Marek. 2020. ACS Catal. 2020, 10, 5793−5804

2) Nucleophilic Substitution at Quaternary Carbon Stereocenters

Veeranjaneyulu Lanke and Ilan Marek

2020. Am. Chem. Soc. 2020, 142, 5543-5548 Corrections: J. Am. Chem. Soc. 2020, 142, 7710-7712

3) Pd-Catalyzed Enantioselective Hydroalkynylation of Cyclopropenes

Longyang Dian and Ilan Marek 2020. ACS Catalysis, 2020, 10, 1289-1293

4) Enantioselective Synthesis of Vicinal Tertiary and Quaternary Carbon Stereogenic Centers Within an Acyclic Chain

David Pierrot and Ilan Marek 2020. Chem. Int. Ed. 2020, 59, 36-49

5) Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three-Membered Carbocycles

Zhi-Qi Zhang, Meng-Meng Zheng, Xiao-Song Xue, Ilan Marek, Fa-Guang Zhang, Jun-An Ma

2019. Chem. Int. Ed. 2019, 58, 18191-18196

6) Diastereoselective Ring Opening of Fully-Substituted Cyclopropanes via Intramolecular Friedel–Crafts Alkylation

Veerujaneyulu Lanke, Fa-Guang Zhang, Alexander Kaushansky and Ilan Marek

2019. Science 2019, 10, 9548-9554

7) Regio- and Stereoselective Synthesis of Fully Substituted Silyl Enol Ethers of Ketones and Aldehydes in Acyclic Systems.

Peter-Yong Wang, Guillaume Duret and Ilan Marek

2019. Chem. Int. Ed. 2019, 58, 14995-14999

8) Regio- and Diastereoselective Copper-Catalyzed Carbometalation of Cyclopropenylsilanes

Yair Cohen and Ilan Marek

2019. Organic Letters 2019, 21, 9162-9165

9) Highly E-selective, Stereoconvergent Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Alkenyl Ethers

Guo-Ming Ho, Heiko Sommer and Ilan Marek

2019. Lett 2019, 21, 2913-2917

10) A Tandem Iridium-catalyzed ‘Chain-walking’/Cope Rearrangement Sequence

Heiko Sommer, Tal Weissbrod and Ilan Marek

2019. ACS Catalysis, 2019, 9, 2400-2406

11) Diastereo- and Enantioselective Preparation of Cyclopropanol and Cyclopropylamine Derivatives

Marwan Simaan and Ilan Marek

2019. Beilstein Journal of Organic Chemistry, 2019, 15, 752-760

12) Versatility in the Brook Rearrangement for Selective Ring-Opening of Three-Membered Rings Coralie Tugny, Fa-Guang Zhang and Ilan Marek

Coralie Tugny, Fa-Guang Zhang and Ilan Marek

2019. Eur. J. 2019, 25, 205-209

13) Convergent and Flexible Approach to Stereodefined Polyhydroxylated Fragments

Alexander Shtrenberg, Elvira Haimov, Polina Smirnov and Ilan Marek

2018. Tetrahedron (special issue for Prof. Leon Ghosez), 2018, 74, 6761-6768

14) Diastereoselective Ring Opening of Alkenylcyclopropanes: Application to the Total Synthesis of C30 Botryococcene and epi-Botryococcene

Morgan Cormier, Aurelien de la Torre and Ilan Marek

2018. Chem. Int. Ed. 2018, 58, 13237-13241.

15) Efficient and Stereodivergent Synthesis of Unsaturated Acyclic Fragments Bearing Contiguous Stereogenic Elements

Jeffrey Bruffaerts, David Pierrot and Ilan Marek

2018. Nature Chemistry, 2018, 10, 1164-1170

16) Asymmetric Preparation of Polysubstituted Cyclopropanes Based on Direct Functionalization of Achiral Three-Membered Carbocycles

Longyang Dian and Ilan Marek

2018. Chemical Reviews (Focus) 2018, 118, 8415-8434

Full List of Publications

Name Surname Position Room Office E-mail
Itai Massad PhD student 606 5567
Yong Peter Wang PhD student 606 5567
Anthony Cohen PhD student 606 5567
Yair Cohen PhD student 605 3709
Yogesh Siddaraju Post-doc 606 5567
Lucas Segura MSc student 606 5567
Rahul Shuresh PhD student 606 5567
Guo-Ming Ho Post-doc 606 5567
Veeru Lanke Post-doc 606 5567
Jean Chagneau Project 606 5567
Laura Levy Project 606 5567
Yael Nir Research assistant 606 5567
Kaushalendra Patel PhD student 606 5567
Augustin Andre-Uwe Post-doc 606 5567