Organic and Inorganic Chemistry Literature Seminar: Mechanochemistry For Organic Synthesis

Organic and Inorganic Chemistry Literature Seminar: Mechanochemistry For Organic Synthesis

April 2nd

חדר סמינרים

9:30

Ms. Yuliya Goldshtein from the Apeloig group

Mechanochemistry for organic synthesis
In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. A major inspiration for it has been the emergence of Green chemistry, accompanied by a growing need for transformations that are cleaner, safer, and more efficient than the ones currently in place. A hallmark of mechanochemistry is the use of grinding or milling to achieve chemical transformations without a need for solvents, which is particularly attractive in developing environmentally friendly processes. Many additional advantages, including reaction telescoping, higher yields, and better selectivities, together with greater safety, have been reported for mechanochemical reactions. Therefore, mechanochemistry found great use in many applications, not only in organic and organometallic syntheses, but also in metal and enzymatic catalysis, in co-crystal formulations, metal-organic framework (MOF) preparations, and in the synthesis of active pharmaceutical materials and ingredients (APIs). Moreover, this technique has gained even greater attention thanks to its ability to allow reactions to take new reactive paths, thus “unlocking” novel compounds that would be inaccessible via conventional synthetic methods.
My talk will provide a brief overview of recent advances in the use of mechanochemical techniques for organic synthesis, highlighting selected examples of mechanochemical organic transformations that remained elusive to conventional solution-based techniques.