Physical and Analytical Chemistry Seminar
Lecturer: Prof. Kazuhiko Nakatani
Location: Faculty Seminar Room
Having completed the human genome sequencing and subsequent ENCODE project, non-coding RNAs are now well realized to play important roles on regulating our life, and are, therefore, prominent targets for next generation drugs. We have focused our research on recognition of characteristic structures of DNA and RNA by small molecules and on regulation of their structure and functions. In the talk, I will briefly show how we succeeded in the recognition of mismatched base pairs in double stranded DNA, and further extension to the recognition of trinucleotide repeat sequence, which is the causative of many neurological diseases, and focus on regulation of RNA secondary structure and function.