Synthetic organic chemistry

Porphyrins and related macrocycles are considered the “pigments of life; and the development of synthetic methodologies remains a vibrant field for many decades. The Zeev Gross group’s discovery on the synthesis of what remains the most stable and accessible corrole to date created an enormous flurry of research activity on corrole-chelated metal complexes. Ongoing projects focus on specifically designed derivatives that are tailor-made for specific applications. Examples are amphipolar metallocorroles as drug candidates, derivatives with supramolecular motifs for inducing selectivity in catalysis, and tuning of photophysical properties via synthetic manipulations for the design of photocatalysts.

The Marek group is concerned with the design and development of new and efficient stereo- and enantioselective strategies for the synthesis of important complex molecular structures. We are particularly interested in developing carbon-carbon bond forming processes, which efficiently create multiple stereocenters in a single-pot operation. Deep understanding of reaction mechanisms gives insight into the origins of chemo- and stereoselectivity, and governs optimization towards the most efficient and general protocols for our methodologies. Our vision is that we should provide an answer to challenging synthetic problems but it has to be coupled with unique efficiency and elegance.