member-academic-staff
Zeev Gross

Zeev Gross

Professor
+972-4-8293954
+972-4-8295703
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The research in our group is focused on the rational design of new corrole complexes for multiple purposes. After tuning their chemical and photophysical properties by selective synthesis protocols that we devise, the corrole derivatives are introduced as key elements for a variety of applications: catalysis, small molecule activation, catalytic oxidation/reduction of water, drug development, and more.

The tools applied by the research group include organic and inorganic synthesis, physical-organic methodologies, advanced spectroscopy, and electrochemistry, as well as biochemical protocols. Our 1999 discovery on the synthesis of what remains the most stable and accessible corrole to date created an enormous flurry of research activity on corrole-chelated metal complexes. This is reflected in the transition from what used to be no more than a scientific curiosity to a highly vibrant field. As of 2017, 150 out of the 180 publications that we have published are on corroles and we hold 7 patents on these molecules and their utility.
On top of fundamental research, we are promoting practical aspects in the fields of asymmetric catalysis, alternative energy, and drug development.

Main projects:

· Coordination chemistry: stability of high-valent & reactivity of low-valent corrole-chelated metal complexes; controlling photophysical and chemical properties of metallocorroles. Fig1

· Catalysis: Development/improvement of new/known catalytic processes with emphasis on full characterization of the catalytic cycle and the various reaction intermediates. Fig2

· Energy: Recent focus is on alternative energy and fuel cells, which includes the development of new chromophores for dye sensitized solar cells, the design of catalysts for the 4-electron/4-protons reduction of oxygen to water, the hydrogen evolution reaction, and for water oxidation (the oxygen evolution reaction). Another relevant approach is to take advantage of the strong reducing power of metallocorroles for the activation of small molecules/ions like carbon dioxide and halides. Fig3

· Medicine: Group members who are involved in the medicine-oriented projects perform the biochemical and biological investigations by themselves, in collaborations with research groups from the Technion’s medical school. The relevance of chemistry-only results regarding catalytic decomposition of reactive oxygen and nitrogen species are currently demonstrated in atherosclerosis, diabetes, neurodegenerative diseases, and cancer. The last aspect and some novel imaging procedures are also being developed within a large collaboration in South California (Caltech, City of Hope, and Cedars Sinai Medical Center). Fig4

Post doc: Princeton University, Princetion, NJ, USA, 1988-1990 in the field of porphyrin chemistry (under JT Groves)

Ph.D: Bar Ilan University, Ramat Gan, Israel, 1987, in Physical Organic Chemistry

 

Awards

Fulbright postdoctoral fellowship, 1988.

Koebner-Klein award for starting faculty members, 1991.

Henri Gutwirth award for excellence in research, 1995.

Ray and Miriam Klein award for “The development of porphyrin-like catalysts for asymmetric catalysis”, 1999.

Mitchel award for the promotion of inventions with commercial potential, 4/2000.

Hershel Rich – Technion Innovation Award, 5/2000.

Henry Taub Prize for Excellence in Research – 5/2003.

The Reba May & Robert D. Blum Named Professorship (“Kathedra”) – 2/2004.

Schulich Award for Excellence in teaching, 2009

Hershel & Hilda Rich Innovation Award, 6/2013

Moore Distinguished Scholar, Caltech, 8/2013

Israel Chemical Society Award for the Outstanding Scientist, 2/2014

  • Soll, M.; Bar Am, O.; Mahammed, A.; Saltsman, I.; Mandel, S.; Youdim, M. B. H.; Gross, Z. “Neurorescue by a ROS Decomposition Catalyst” ACS Chem. Neurosci. 2016, in press.
  • Vestfrid, J.; Kothari, R.; Kostenko, A.; Goldberg, I.; Tumanskii, B.; Gross, Z. “Intriguing Physical and Chemical Properties of Phosphorus Corroles” Chem. 2016, 55 (12), 6061–6067.
  • Levy, N.; Mahammed, A.; Kosa, M.; Major, D. T.; Gross, Z.; Elbaz, L. “Metallocorroles as Nonprecious-Metal Catalysts for Oxygen Reduction” Chemie – Int. Ed. 2015, 54 (47), 14080–14084.
  • Mahammed, A.; Gross, Z. “Metallocorroles as Photocatalysts for Driving Endergonic Reactions, Exemplified by Bromide to Bromine Conversion.” Chem. Int. Ed. Engl. 2015, 54 (42), 12370-12373.
  • Pohl, J.; Saltsman, I.; Mahammed, A.; Gross, Z.; Röder, B. “Inhibition of green algae growth by corrole-based photosensitizers.” Appl. Microbiol. 2015, 118 (2), 305–312.
  • Haber, A.; Gross, Z. “Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.” Commun. 2015, 51, 5812–5827.
  • Teo, R. D.; Gray, H. B.; Lim, P.; Termini, J.; Domeshek, E.; Gross, Z. “A cytotoxic and cytostatic gold(III) corrole.” Commun. 2014, 50, 13789–13792.
  • Mahammed, A.; Mondal, B.; Rana, A.; Dey, A.; Gross, Z. “The cobalt corrole catalyzed hydrogen evolution reaction: surprising electronic effects and characterization of key reaction intermediates.” Commun. 2014, 50 (21), 2725–2727.
  • Hwang, J. Y.; Wachsmann-Hogiu, S.; Ramanujan, V. K.; Ljubimova, J.; Gross, Z.; Gray, H. B.; Medina-Kauwe, L. K.; Farkas, D. L. “A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment.” Imaging Biol. 2012, 14 (4), 431–442.
  • Okun, Z.; Gross, Z. “Fine tuning the reactivity of corrole-based catalytic antioxidants.” Chem. 2012, 51 (15), 8083–8090.
  • Schechter, A.; Stanevsky, M.; Mahammed, A.; Gross, Z. “Four-electron oxygen reduction by brominated cobalt corrole” Chem. 2012, 51 (1), 22–24.
  • Nigel-Etinger, I.; Mahammed, A.; Gross, Z. “Covalent versus non-covalent (biocatalytic) approaches for enantioselective sulfoxidation catalyzed by corrole metal complexes” Sci. Technol. 2011, 1 (4), 578.
  • Aviv-Harel, I.; Gross, Z. “Coordination chemistry of corroles with focus on main group elements” Chem. Rev. 2011, 255 (7–8), 717–736.

Name Email Room Phone
Dr. Atif Mahammed chatif@technion.ac.il 509 2681
Dr. Irena Saltsman saltsman@technion.ac.il 510 3731
Dr. Amir Mizrahi amirmizrachi@gmail.com 509 2681
Dr. Sudhakar Kolanu kolanusudhakar@gmail.com 509 2681
Dr. Woormileela Sinha w.sinha@technion.ac.il 509 2681
Jenya Vestfrid juka@technion.ac.il 510 3731
Matan Soll ssolliwa@technion.ac.il 509 2681
Elena Landau-Aize lena.aize@gmail.com‏ 510 3731
Peter Teplitzki petert09@gmail.com 509/510 3731/2861
Anh Le anhle@technion.ac.il 509 2861
Qiucheng Chen qiuchengchen@campus.technion.ac.il 509 2681
xuan zhan xuan-zhan@campus.technion.ac.il 509 2681