Physical and Analytical Chemistry Seminar
Lecturer: Dr. Ron Gill
Location: Faculty Seminar Room
Noble metal nanoparticles support surface plasmons that leads to very strong interaction between the nanoparticles and electromagnetic fields. This leads to an electromagnetic field enhancement around the nanoparticles which can be used to increase the light-matter interaction with nearby molecules leading to such phenomena as surface enhanced Raman scattering (SERS) and surface enhanced fluorescence (SEF). At the same time the wavelength in which nanoparticles exhibit this plasmon resonance is dependent on the dielectric environment around them, giving rise to the possibility to detect binding events on the nanoparticle surface by change in the localized surface plasmon resonance (LSPR).
In my talk I will give examples how these phenomena were used in bioanalytical applications related to the detection and quantification of biomacromolecules such as DNA, RNA and proteins. The drive to solve specific analytical applications lead us to go beyond simple proof of principle demonstrations of the usefulness of nano-related phenomena in bioanalytical systems and into exploring issues such as precision, working in complex fluids, and readout with common bioanalytical lab equipment.